Tramadol is a synthetic opioid and acts in the brain and spine (central nervous system) to reduce the amount of pain you feel. Tramadol is a strong pain medication used to treat moderate to severe pain that is not being relieved by other types of pain medicines. Medically reviewed by Melisa Puckey, BPharm. Brand names: ConZip, Qdolo, Ultram, Ultram ERĭrug class: Opioids (narcotic analgesics)